Molecular Imaging Unravels Cerebral Malaria

Molecular basis of human cerebral malaria development

Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, wh...

Imaging cerebral malaria with a susceptibility-weighted MR sequence.

MR Sequence Cerebral malaria is a severe complication seen in approximately 2% of patients with acute Plasmodium falciparum infection. Characteristic diffuse petechial hemorrhages that were previously only seen by gross pathologic or microscopic examination, and virtually undetectable by conventional imaging modalities, were well demonstrated in a patient with cerebral malaria, with use of susc...

Cerebral malaria.

Cerebral malaria is the most important manifestation of severe Plasmodium falciparum infection. The clinical picture in South East Asian adults differs from that in African children. The children are more likely to have abnormal brain stem reflexes, signs suggestive of cerebral herniation, and raised CSF opening pressure, and to suffer persistent neurological sequelae. The mortality remains hig...

Cerebral Malaria

Cerebral Malaria